Probe Summary
Selectivity
Target Potency
In Vivo
Control Compounds
Chemical Information
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Probe Summary
| Protein target(s) | FFAR1 Agonist |
| Biochemical/Biophysical Potency | |
| Cellular Potency | EC50: 36 nM , EC50: 3.6 nM |
| Recommended concentration for cellular use | up to 1 uM |
Selectivity
Potency
In Cell
In Vitro
FFAR1
Mode of Action: Agonist
Structure-Activity-Relationship data available? Yes
DOI Reference: 10.1021/ml400501x
In Vivo Validations
Rat, Dog, Cyno
Dose: 0.5 mg/Kg IP, 2 mg/Kg PO
Route of delivery:
Intravenous, Oral
Plasma half life:
5.3 (R), 5.6 (D), 14 (C) h
Systemic clearance:
0.09 (R), 0.15 (D), 0.04 (C) L/h/Kg
DOI Reference: 10.1021/ml400501x
Chemical Information
| Molecular Formula | C24H19F3N2O4S |
| SMILEs | Cc1nc(-c2ccc(C(F)(F)F)cc2)sc1COc1ccc([C@H](CC(=O)O)c2ccon2)cc1 |
| InChI | InChI=1S/C24H19F3N2O4S/c1-14-21(34-23(28-14)16-2-6-17(7-3-16)24(25,26)27)13-32-18-8-4-15(5-9-18)19(12-22(30)31)20-10-11-33-29-20/h2-11,19H,12-13H2,1H3,(H,30,31)/t19-/m0/s1 |
| Molecular weight | 488.10 Da |
| AlogP | 6.31092 |
| HBond acceptors | 6 |
| HBond donors | 1 |
| Atoms | 53 |